Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Id http://purl.obolibrary.org/obo/NCIT_C769
http://purl.obolibrary.org/obo/NCIT_C769
Preferred Name

Prednisolone
Definitions
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)
label
Prednisolone
prefLabel
Prednisolone
Legacy Concept Name
Prednisolone
in_subset
Preferred_Name
Prednisolone
Is_Value_For_GDC_Property
Chemical_Formula
C21H28O5
Display_Name
Prednisolone
Maps_To
Prednisolone
PDQ_Open_Trial_Search_ID
43296
UMLS_CUI
C0032950
FDA_UNII_Code
9PHQ9Y1OLM
prefixIRI
NCIT:C769
Accepted_Therapeutic_Use_For
Inflammatory conditions; Allergic conditions; Hematologic conditions; Neoplastic conditions; Autoimmune conditions; Replacement therapy in adrenal insufficiency
NCI_Drug_Dictionary_ID
43296
Contributing_Source
CTRP
FDA
subClassOf
CHEBI_ID
CHEBI:8378
code
C769
type
ALT_DEFINITION
A drug that lessens inflammation and suppresses the body's immune response. It may also kill cancer cells. Prednisolone is used to treat disorders in many organ systems and to treat the symptoms of several types of leukemia and lymphoma. It is also being studied in the treatment of other types of cancer. Prednisolone is a type of therapeutic glucocorticoid.
NSC Number
9120
PDQ_Closed_Trial_Search_ID
43296
Semantic_Type
Organic Chemical
Pharmacologic Substance
CAS_Registry
50-24-8
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