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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C768
http://purl.obolibrary.org/obo/NCIT_C768
|
|---|---|
| Preferred Name | Prednimustine |
| Definitions |
The prednisolone ester of chlorambucil and nitrogen mustard alkylating agent with antineoplastic activity. Prednimustine itself is not cytotoxic, however, it becomes cytotoxic upon hydrolysis by serum esterases to chlorambucil. Therefore, the increased potency of prednimustine is linked to the prolonged availability of free chlorambucil.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The prednisolone ester of chlorambucil and nitrogen mustard alkylating agent with antineoplastic activity. Prednimustine itself is not cytotoxic, however, it becomes cytotoxic upon hydrolysis by serum esterases to chlorambucil. Therefore, the increased potency of prednimustine is linked to the prolonged availability of free chlorambucil. |
|---|---|
| label | Prednimustine
|
| prefLabel | Prednimustine
|
| Legacy Concept Name | Prednimustine
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| in_subset | |
| Preferred_Name | Prednimustine
|
| Is_Value_For_GDC_Property | |
| Chemical_Formula | C35H45Cl2NO6
|
| Maps_To | Prednimustine
|
| PDQ_Open_Trial_Search_ID | 39560
|
| UMLS_CUI | C0032949
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| FDA_UNII_Code | 9403SIO2S8
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| prefixIRI | NCIT:C768
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| NCI_Drug_Dictionary_ID | 39560
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| Contributing_Source | FDA
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| subClassOf | |
| code | C768
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| type | |
| NSC Number |
134087
171345
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| PDQ_Closed_Trial_Search_ID | 39560
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 29069-24-7
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| Delete | Subject | Author | Type | Created |
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