Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Jump to:
loading...
Preferred Name

Vardenafil Hydrochloride Trihydrate
Synonyms
Definitions

The hydrochloride salt form of vardenafil, a benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonging penile erection.
ID

http://purl.obolibrary.org/obo/NCIT_C76318
CAS_Registry

330808-88-3
Chemical_Formula

C23H32N6O4S.ClH.3H2O
code

C76318
Contributing_Source

FDA
definition

The hydrochloride salt form of vardenafil, a benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonging penile erection.
FDA_UNII_Code

5M8S2CU0TS
Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C66650
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424
label

Vardenafil Hydrochloride Trihydrate
Legacy Concept Name

Vardenafil_Hydrochloride
NCI_Drug_Dictionary_ID

670474
PDQ_Closed_Trial_Search_ID

670474
PDQ_Open_Trial_Search_ID

670474
Preferred_Name

Vardenafil Hydrochloride Trihydrate
prefixIRI

NCIT:C76318
prefLabel

Vardenafil Hydrochloride Trihydrate
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C1960918
subClassOf

http://purl.obolibrary.org/obo/NCIT_C2127
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display