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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C763
http://purl.obolibrary.org/obo/NCIT_C763
|
|---|---|
| Preferred Name | Porfiromycin |
| Definitions |
An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. (NCI04) |
|---|---|
| prefLabel | Porfiromycin
|
| label | Porfiromycin
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| PDQ_Closed_Trial_Search_ID | 39610
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| code | C763
|
| prefixIRI | NCIT:C763
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| in_subset | |
| Preferred_Name | Porfiromycin
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| FDA_UNII_Code | H1WK901OA6
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| Contributing_Source | FDA
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| Chemical_Formula | C16H20N4O5
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| Maps_To | Porfiromycin
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| CAS_Registry | 801-52-5
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| NSC Number | 56410
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| NCI_Drug_Dictionary_ID | 39610
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| Legacy Concept Name | Porfiromycin
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39610
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0032697
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| Delete | Subject | Author | Type | Created |
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