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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C76266
http://purl.obolibrary.org/obo/NCIT_C76266
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|---|---|
| Preferred Name | Vinflunine Ditartrate |
| Definitions |
The ditartrate salt of vinflunine, a bi-fluorinated derivative of the semisynthetic vinca alkaloid vinorelbine with potential antimitotic and antineoplastic activities. Vinflunine binds to tubulin and inhibits tubulin assembly and disrupts microtubule assembly dynamics. This results in cell cycle arrest in mitosis and an induction of apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The ditartrate salt of vinflunine, a bi-fluorinated derivative of the semisynthetic vinca alkaloid vinorelbine with potential antimitotic and antineoplastic activities. Vinflunine binds to tubulin and inhibits tubulin assembly and disrupts microtubule assembly dynamics. This results in cell cycle arrest in mitosis and an induction of apoptosis. |
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| label | Vinflunine Ditartrate
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| prefLabel | Vinflunine Ditartrate
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| Has_Free_Acid_Or_Base_Form | |
| Legacy Concept Name | Vinflunine_Ditartrate
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| in_subset | |
| Preferred_Name | Vinflunine Ditartrate
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C45H54F2N4O8.2C4H6O6
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| Maps_To | Vinflunine Ditartrate
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| UMLS_CUI | C2700251
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| FDA_UNII_Code | 33MG53C7XW
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| prefixIRI | NCIT:C76266
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| Contributing_Source | FDA
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| subClassOf | |
| code | C76266
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of bladder cancer, lung cancer, and other types of cancer.
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 194468-36-5
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