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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C75998
http://purl.obolibrary.org/obo/NCIT_C75998
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|---|---|
| Preferred Name | Taltobulin |
| Definitions |
An analogue of the naturally occurring tripeptide hemiasterlin, with potential antimitotic and antineoplastic activities. Taltobulin binds tubulin in a similar manner as colchicine and inhibits tubulin polymerization. This results in the disruption of the cytoskeleton, ultimately leading to cell cycle arrest in G2/M phase, blockage of cell division and apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An analogue of the naturally occurring tripeptide hemiasterlin, with potential antimitotic and antineoplastic activities. Taltobulin binds tubulin in a similar manner as colchicine and inhibits tubulin polymerization. This results in the disruption of the cytoskeleton, ultimately leading to cell cycle arrest in G2/M phase, blockage of cell division and apoptosis. |
|---|---|
| prefLabel | Taltobulin
|
| label | Taltobulin
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| code | C75998
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| prefixIRI | NCIT:C75998
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| in_subset | |
| Preferred_Name | Taltobulin
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| FDA_UNII_Code | J6D6912BXS
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| Contributing_Source | FDA
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| Chemical_Formula | C27H43N3O4
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| Maps_To | Taltobulin
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| CAS_Registry | 228266-40-8
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| Legacy Concept Name | Taltobulin
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1258191
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