Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C75228
http://purl.obolibrary.org/obo/NCIT_C75228
Preferred Name

Nocodazole
Definitions
A synthetic tubulin-binding agent with antineoplastic activity. Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics. This prevents mitosis and induces apoptosis in tumor cells. Although nocodazole binding site overlaps with that of colchicine, the two agents are structurally quite different.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic tubulin-binding agent with antineoplastic activity. Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics. This prevents mitosis and induces apoptosis in tumor cells. Although nocodazole binding site overlaps with that of colchicine, the two agents are structurally quite different.
label
Nocodazole
prefLabel
Nocodazole
Legacy Concept Name
Nocodazole
in_subset
Preferred_Name
Nocodazole
Is_Value_For_GDC_Property
Chemical_Formula
C14H11N3O3S
Maps_To
Nocodazole
UMLS_CUI
C0028247
FDA_UNII_Code
SH1WY3R615
prefixIRI
NCIT:C75228
Contributing_Source
FDA
subClassOf
CHEBI_ID
CHEBI:34892
code
C75228
type
Semantic_Type
Pharmacologic Substance
CAS_Registry
31430-18-9
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