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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C75148
http://purl.obolibrary.org/obo/NCIT_C75148
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|---|---|
| Preferred Name | Puromycin Hydrochloride |
| Definitions |
The hydrochloride salt form of puromycin, an aminoglycoside antibiotic isolated from the bacterium Streptomyces alboniger. Acting as an analog of the 3' terminal end of aminoacyl-tRNA, puromycin incorporates itself into a growing polypeptide chain and causes its premature termination, thereby inhibiting protein synthesis. This agent has antimicrobial, antitrypanosomal, and antineoplastic properties; it is used as an antibiotic in cell culture.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt form of puromycin, an aminoglycoside antibiotic isolated from the bacterium Streptomyces alboniger. Acting as an analog of the 3' terminal end of aminoacyl-tRNA, puromycin incorporates itself into a growing polypeptide chain and causes its premature termination, thereby inhibiting protein synthesis. This agent has antimicrobial, antitrypanosomal, and antineoplastic properties; it is used as an antibiotic in cell culture. |
|---|---|
| label | Puromycin Hydrochloride
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| prefLabel | Puromycin Hydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| Legacy Concept Name | Puromycin_Hydrochloride
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| in_subset | |
| Preferred_Name | Puromycin Hydrochloride
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C22H29N7O5.2HCl
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| Maps_To | Puromycin Hydrochloride
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| UMLS_CUI | C0282329
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| FDA_UNII_Code | PGN54228S5
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| prefixIRI | NCIT:C75148
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| Contributing_Source | FDA
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| subClassOf | |
| code | C75148
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| type | |
| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 58-58-2
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