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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C75124
http://purl.obolibrary.org/obo/NCIT_C75124
|
|---|---|
| Preferred Name | Topixantrone |
| Definitions |
A 9-aza-anthrapyrazole antineoplastic antibiotic. Topixantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Compared to other DNA intercalators, this agent shows minimal cardiotoxicity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A 9-aza-anthrapyrazole antineoplastic antibiotic. Topixantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Compared to other DNA intercalators, this agent shows minimal cardiotoxicity. |
|---|---|
| prefLabel | Topixantrone
|
| label | Topixantrone
|
| code | C75124
|
| prefixIRI | NCIT:C75124
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| in_subset | |
| Preferred_Name | Topixantrone
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| FDA_UNII_Code | R40RXC296C
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| Contributing_Source | FDA
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| Chemical_Formula | C21H26N6O2
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| Maps_To | Topixantrone
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| CAS_Registry | 156090-18-5
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| Legacy Concept Name | Topixantrone
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C1528075
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| Delete | Subject | Author | Type | Created |
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