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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74554
http://purl.obolibrary.org/obo/NCIT_C74554
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|---|---|
| Preferred Name | Aminopterin Sodium |
| Definitions |
The sodium salt of a pterin derivative with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt of a pterin derivative with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04) |
|---|---|
| prefLabel | Aminopterin Sodium
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| label | Aminopterin Sodium
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| code | C74554
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| prefixIRI | NCIT:C74554
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| in_subset | |
| Preferred_Name | Aminopterin Sodium
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| FDA_UNII_Code | FZU1QI13O9
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| Contributing_Source | FDA
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| Chemical_Formula | C19H18N8O5.2Na
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| Maps_To | Aminopterin Sodium
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| CAS_Registry | 58602-66-7
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| Legacy Concept Name | Aminopterin_Sodium
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0282048
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