Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C741
http://purl.obolibrary.org/obo/NCIT_C741
|
|---|---|
| Preferred Name | Phenytoin |
| Definitions |
A hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation. |
|---|---|
| prefLabel | Phenytoin
|
| label | Phenytoin
|
| Has_Salt_Form | |
| CHEBI_ID | CHEBI:8107
|
| code | C741
|
| prefixIRI | NCIT:C741
|
| in_subset | |
| Preferred_Name | Phenytoin
|
| FDA_UNII_Code | 6158TKW0C5
|
| Contributing_Source | FDA
|
| Chemical_Formula | C15H12N2O2
|
| CAS_Registry | 57-41-0
|
| Legacy Concept Name | Phenytoin
|
| type | |
| subClassOf | |
| Accepted_Therapeutic_Use_For | Epilepsy
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0031507
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |