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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74082
http://purl.obolibrary.org/obo/NCIT_C74082
|
|---|---|
| Preferred Name | Thioredoxin-1 Inhibitor PX-12 |
| Definitions |
An orally bioavailable small molecule with potential antineoplastic activity. Thioredoxin-1 inhibitor PX-12 irreversibly binds to thioredoxin-1 (Trx-1) and inhibits its activity, which may result in growth inhibition and the induction of apoptosis. Overexpressed in many cancer cell types, the low molecular weight redox protein Trx-1 regulates transcription factor activity and inhibits apoptosis, promoting cell growth and survival; it also interacts with growth factors extracellularly to stimulate cell growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable small molecule with potential antineoplastic activity. Thioredoxin-1 inhibitor PX-12 irreversibly binds to thioredoxin-1 (Trx-1) and inhibits its activity, which may result in growth inhibition and the induction of apoptosis. Overexpressed in many cancer cell types, the low molecular weight redox protein Trx-1 regulates transcription factor activity and inhibits apoptosis, promoting cell growth and survival; it also interacts with growth factors extracellularly to stimulate cell growth. |
|---|---|
| prefLabel | Thioredoxin-1 Inhibitor PX-12
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| label | Thioredoxin-1 Inhibitor PX-12
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| PDQ_Closed_Trial_Search_ID | 590656
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| code | C74082
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| Has_Target | |
| prefixIRI | NCIT:C74082
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| in_subset |
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| Display_Name | Thioredoxin-1 Inhibitor PX-12
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| Preferred_Name | Thioredoxin-1 Inhibitor PX-12
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| FDA_UNII_Code | 8PQ9CZ8BTJ
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Thioredoxin-1 Inhibitor PX-12
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| CAS_Registry | 141400-58-0
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| NCI_Drug_Dictionary_ID | 590656
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| Legacy Concept Name | Thioredoxin-1_Inhibitor_PX-12
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 590656
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0960559
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