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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74073
http://purl.obolibrary.org/obo/NCIT_C74073
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|---|---|
| Preferred Name | PI3K Inhibitor BGT226 |
| Definitions |
A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins. |
|---|---|
| prefLabel | PI3K Inhibitor BGT226
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| label | PI3K Inhibitor BGT226
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| PDQ_Closed_Trial_Search_ID | 587478
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| code | C74073
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| Has_Target | |
| prefixIRI | NCIT:C74073
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| in_subset |
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| Display_Name | PI3K Inhibitor BGT226
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| Preferred_Name | PI3K Inhibitor BGT226
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| Contributing_Source | CTRP
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| Maps_To | PI3K Inhibitor BGT226
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| NCI_Drug_Dictionary_ID | 587478
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| Legacy Concept Name | PI3K_Inhibitor_BGT226
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 587478
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2347426
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