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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74070
http://purl.obolibrary.org/obo/NCIT_C74070
|
|---|---|
| Preferred Name | PEP-3-KLH Conjugate Vaccine |
| Definitions |
A cancer vaccine consisting of PEP-3, a synthetic peptide encompassing a tumor-specific mutated segment of the epidermal growth factor receptor type vIII (EGFRvIII), conjugated to the naturally-occurring immunoadjuvant keyhole limpet hemocyanin (KLH) with potential immunostimulating and antineoplastic activities. Upon administration, PEP-3-KLH conjugate vaccine may induce a cytotoxic immune response against tumor cells that overexpress EGFRvIII; this antitumoral immune response may involve antibody-dependent cellular cytotoxicity (ADCC).
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cancer vaccine consisting of PEP-3, a synthetic peptide encompassing a tumor-specific mutated segment of the epidermal growth factor receptor type vIII (EGFRvIII), conjugated to the naturally-occurring immunoadjuvant keyhole limpet hemocyanin (KLH) with potential immunostimulating and antineoplastic activities. Upon administration, PEP-3-KLH conjugate vaccine may induce a cytotoxic immune response against tumor cells that overexpress EGFRvIII; this antitumoral immune response may involve antibody-dependent cellular cytotoxicity (ADCC). |
|---|---|
| prefLabel | PEP-3-KLH Conjugate Vaccine
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| label | PEP-3-KLH Conjugate Vaccine
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| PDQ_Closed_Trial_Search_ID | 391254
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| code | C74070
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| Has_Target | |
| prefixIRI | NCIT:C74070
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| in_subset |
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| Display_Name | PEP-3-KLH Conjugate Vaccine
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| Preferred_Name | PEP-3-KLH Conjugate Vaccine
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| Contributing_Source | CTRP
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| Maps_To | PEP-3-KLH Conjugate Vaccine
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| NCI_Drug_Dictionary_ID | 391254
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| Legacy Concept Name | PEP-3-KLH_Conjugate_Vaccine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 391254
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1541477
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