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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74060
http://purl.obolibrary.org/obo/NCIT_C74060
|
|---|---|
| Preferred Name | MET Tyrosine Kinase Inhibitor BMS-777607 |
| Definitions |
An inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis. |
|---|---|
| prefLabel | MET Tyrosine Kinase Inhibitor BMS-777607
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| label | MET Tyrosine Kinase Inhibitor BMS-777607
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| PDQ_Closed_Trial_Search_ID | 587999
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| code | C74060
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| prefixIRI | NCIT:C74060
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| in_subset | |
| Preferred_Name | MET Tyrosine Kinase Inhibitor BMS-777607
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| FDA_UNII_Code | A3MMS6HDO1
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| Contributing_Source | FDA
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| Maps_To | MET Tyrosine Kinase Inhibitor BMS-777607
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| CAS_Registry | 1025720-94-8
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| NCI_Drug_Dictionary_ID | 587999
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| Legacy Concept Name | MET_Tyrosine_Kinase_Inhibitor_BMS-777607
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 587999
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2346911
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| Delete | Subject | Author | Type | Created |
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