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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74051
http://purl.obolibrary.org/obo/NCIT_C74051
|
|---|---|
| Preferred Name | Iodine I 125-Anti-EGFR-425 Monoclonal Antibody |
| Definitions |
A radioimmunoconjugate consisting of a murine IgG2a monoclonal antibody directed against the human epidermal growth factor receptor (EGFR) labeled with iodine I 125 with potential antineoplastic activity. Iodine I 125 anti-EGFR-425 monoclonal antibody binds specifically to the epidermal growth factor receptor (EGFR). Upon binding to EGFR-expressing tumor cells, this agent is internalized, selectively delivering a potentially cytotoxic dose of gamma radiation. EGFR is a receptor tyrosine kinase that may be overexpressed on the cell surfaces of various solid tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of a murine IgG2a monoclonal antibody directed against the human epidermal growth factor receptor (EGFR) labeled with iodine I 125 with potential antineoplastic activity. Iodine I 125 anti-EGFR-425 monoclonal antibody binds specifically to the epidermal growth factor receptor (EGFR). Upon binding to EGFR-expressing tumor cells, this agent is internalized, selectively delivering a potentially cytotoxic dose of gamma radiation. EGFR is a receptor tyrosine kinase that may be overexpressed on the cell surfaces of various solid tumors. |
|---|---|
| prefLabel | Iodine I 125-Anti-EGFR-425 Monoclonal Antibody
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| label | Iodine I 125-Anti-EGFR-425 Monoclonal Antibody
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| NCI_META_CUI | CL383810
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| PDQ_Closed_Trial_Search_ID | 586304
|
| code | C74051
|
| prefixIRI | NCIT:C74051
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| in_subset | |
| Preferred_Name | Iodine I 125-Anti-EGFR-425 Monoclonal Antibody
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| Maps_To | Iodine I 125-Anti-EGFR-425 Monoclonal Antibody
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| NCI_Drug_Dictionary_ID | 586304
|
| Legacy Concept Name | Iodine_I_125-Anti-EGFR-425_Monoclonal_Antibody
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 586304
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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