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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74043
http://purl.obolibrary.org/obo/NCIT_C74043
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|---|---|
| Preferred Name | Dual IGF-1R/InsR Inhibitor BMS-754807 |
| Definitions |
An oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity. Dual IGF-IR/InsR inhibitor BMS-754807 binds reversibly to and inhibits the activities of IGF-1R and InsR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R and InsR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in mitogenesis, angiogenesis, and tumor cell survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity. Dual IGF-IR/InsR inhibitor BMS-754807 binds reversibly to and inhibits the activities of IGF-1R and InsR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R and InsR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in mitogenesis, angiogenesis, and tumor cell survival. |
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| prefLabel | Dual IGF-1R/InsR Inhibitor BMS-754807
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| label | Dual IGF-1R/InsR Inhibitor BMS-754807
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| PDQ_Closed_Trial_Search_ID | 583260
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| code | C74043
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| Has_Target | |
| prefixIRI | NCIT:C74043
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| in_subset |
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| Display_Name | Dual IGF-1R/InsR Inhibitor BMS-754807
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| Preferred_Name | Dual IGF-1R/InsR Inhibitor BMS-754807
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| FDA_UNII_Code | W9E3353E8J
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C23H26FN9O
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| Maps_To | Dual IGF-1R/InsR Inhibitor BMS-754807
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| CAS_Registry | 1001350-96-4
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| NCI_Drug_Dictionary_ID | 583260
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| Legacy Concept Name | IGF1R_Antagonist_BMS-754807
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 583260
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2346450
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