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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74038
http://purl.obolibrary.org/obo/NCIT_C74038
|
|---|---|
| Preferred Name | Vismodegib |
| Definitions |
An orally bioavailable small molecule with potential antineoplastic activity. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable small molecule with potential antineoplastic activity. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO. |
|---|---|
| prefLabel | Vismodegib
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| label | Vismodegib
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| PDQ_Closed_Trial_Search_ID | 586417
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| code | C74038
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| Has_Target | |
| prefixIRI | NCIT:C74038
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| in_subset |
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| Display_Name | Vismodegib
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| Preferred_Name | Vismodegib
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| FDA_UNII_Code | 25X868M3DS
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C19H14Cl2N2O3S
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| Maps_To | Vismodegib
|
| CAS_Registry | 879085-55-9
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| NCI_Drug_Dictionary_ID | 586417
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| Legacy Concept Name | Hedgehog_Antagonist_GDC-0449
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It blocks a type of protein involved in tissue growth and repair and may block the growth of cancer cells. It is a type of Hedgehog signaling pathway antagonist.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 586417
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| Accepted_Therapeutic_Use_For | basal cell carcinoma
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2348949
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