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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74022
http://purl.obolibrary.org/obo/NCIT_C74022
|
|---|---|
| Preferred Name | CXCR4 Inhibitor Q-122 |
| Definitions |
An orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the GPCR (G protein-coupled receptor) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; it is also a co-receptor for HIV entry into T cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the GPCR (G protein-coupled receptor) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; it is also a co-receptor for HIV entry into T cells. |
|---|---|
| prefLabel | CXCR4 Inhibitor Q-122
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| label | CXCR4 Inhibitor Q-122
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| PDQ_Closed_Trial_Search_ID | 586491
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| code | C74022
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| Has_Target | |
| prefixIRI | NCIT:C74022
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| in_subset |
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| Display_Name | CXCR4 Inhibitor Q-122
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| Preferred_Name | CXCR4 Inhibitor Q-122
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| FDA_UNII_Code | 69D634Q702
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| Contributing_Source |
CTRP
FDA
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| Maps_To | CXCR4 Inhibitor Q-122
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| CAS_Registry | 897657-95-3
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| NCI_Drug_Dictionary_ID | 586491
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 586491
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2347544
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