Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C74021
http://purl.obolibrary.org/obo/NCIT_C74021
Preferred Name

Apricoxib
Definitions
An orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related metabolic pathways may represent crucial regulators of cellular proliferation and angiogenesis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related metabolic pathways may represent crucial regulators of cellular proliferation and angiogenesis.
prefLabel
Apricoxib
label
Apricoxib
PDQ_Closed_Trial_Search_ID
594363
code
C74021
Has_Target
prefixIRI
NCIT:C74021
in_subset
Display_Name
Apricoxib
Preferred_Name
Apricoxib
FDA_UNII_Code
5X5HB3VZ3Z
Contributing_Source
CTRP
FDA
Chemical_Formula
C19H20N2O3S
Maps_To
Apricoxib
CAS_Registry
197904-84-0
NCI_Drug_Dictionary_ID
594363
Legacy Concept Name
COX-2_Inhibitor_TG01
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
594363
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C1737955
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