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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74007
http://purl.obolibrary.org/obo/NCIT_C74007
|
|---|---|
| Preferred Name | Daratumumab |
| Definitions |
A fully human monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. The binding of anti-CD38 monoclonal antibody to natural killer (NK) cells mimics the normal CD38-CD31 interaction on the NK cell surface. CD38 is also present on multiple myeloma (MM) cells and plasma leukemia cells; this agent may preferentially bind these cells, triggering antitumoral antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). CD38, a cell surface glycoprotein, is present on various immune cells and has been shown to regulate the cytotoxic response of activated NK cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A fully human monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. The binding of anti-CD38 monoclonal antibody to natural killer (NK) cells mimics the normal CD38-CD31 interaction on the NK cell surface. CD38 is also present on multiple myeloma (MM) cells and plasma leukemia cells; this agent may preferentially bind these cells, triggering antitumoral antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). CD38, a cell surface glycoprotein, is present on various immune cells and has been shown to regulate the cytotoxic response of activated NK cells. |
|---|---|
| label | Daratumumab
|
| prefLabel | Daratumumab
|
| Legacy Concept Name | Anti-CD38_Monoclonal_Antibody
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| in_subset |
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| Preferred_Name | Daratumumab
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| Is_Value_For_GDC_Property | |
| Display_Name | Daratumumab
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| Maps_To | Daratumumab
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| PDQ_Open_Trial_Search_ID | 583564
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| Has_Target | |
| UMLS_CUI | C2346802
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| FDA_UNII_Code | 4Z63YK6E0E
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| prefixIRI | NCIT:C74007
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| Accepted_Therapeutic_Use_For | multiple myeloma
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| NCI_Drug_Dictionary_ID | 583564
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C74007
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| type | |
| PDQ_Closed_Trial_Search_ID | 583564
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 945721-28-8
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