Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C74001
http://purl.obolibrary.org/obo/NCIT_C74001
|
|---|---|
| Preferred Name | Tiomolibdate Diammonium |
| Definitions |
An ammonium salt with potential antiangiogenic and antitumor activities. Tetrathiomolybdate has been found to deplete systemic copper reserves through an unknown mechanism. This agent has been shown to inhibit the activities of cuproenzymes, including superoxide dismutase 1 (SOD1) and cytochrome c oxidase (COX), which may contribute to its antiangiogenic and antitumor effects.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An ammonium salt with potential antiangiogenic and antitumor activities. Tetrathiomolybdate has been found to deplete systemic copper reserves through an unknown mechanism. This agent has been shown to inhibit the activities of cuproenzymes, including superoxide dismutase 1 (SOD1) and cytochrome c oxidase (COX), which may contribute to its antiangiogenic and antitumor effects. |
|---|---|
| prefLabel | Tiomolibdate Diammonium
|
| label | Tiomolibdate Diammonium
|
| PDQ_Closed_Trial_Search_ID | 467218
|
| code | C74001
|
| prefixIRI | NCIT:C74001
|
| in_subset | |
| Preferred_Name | Tiomolibdate Diammonium
|
| FDA_UNII_Code | 4V6I63LW1E
|
| Contributing_Source | FDA
|
| Chemical_Formula | MoS4.2H4N
|
| Maps_To | Tiomolibdate Diammonium
|
| CAS_Registry | 15060-55-6
|
| NSC Number |
286644
714598
|
| NCI_Drug_Dictionary_ID | 467218
|
| Legacy Concept Name | Ammonium_Tetrathiomolybdate
|
| type | |
| ALT_DEFINITION | A substance being studied in the treatment of many types of cancer. Ammonium tetrathiomolybdate removes extra copper from the body. Removing the copper may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. Ammonium tetrathiomolybdate is a type of chelating agent and a type of antiangiogenesis agent.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 467218
|
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C0076339
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |