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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C73816
http://purl.obolibrary.org/obo/NCIT_C73816
|
|---|---|
| Preferred Name | Pibrozelesin Hydrobromide |
| Definitions |
The hydrobromide salt form of pibrozelesin, a semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2, with antineoplastic activity. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrobromide salt form of pibrozelesin, a semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2, with antineoplastic activity. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis. |
|---|---|
| prefLabel | Pibrozelesin Hydrobromide
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| label | Pibrozelesin Hydrobromide
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| code | C73816
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| prefixIRI | NCIT:C73816
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| in_subset | |
| Preferred_Name | Pibrozelesin Hydrobromide
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| FDA_UNII_Code | 0481JCC90T
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| Contributing_Source | FDA
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| Chemical_Formula | C32H36BrN5O8.BrH
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| Maps_To | Pibrozelesin Hydrobromide
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| CAS_Registry | 148778-32-9
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| Legacy Concept Name | Pibrozelesin_Hydrobromide
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2347514
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