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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C73591
http://purl.obolibrary.org/obo/NCIT_C73591
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|---|---|
| Preferred Name | Sodium Dichloroacetate |
| Definitions |
The sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting in the inhibition of glycolysis and a decrease in lactate production. This agent may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting in the inhibition of glycolysis and a decrease in lactate production. This agent may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling. |
|---|---|
| prefLabel | Sodium Dichloroacetate
|
| label | Sodium Dichloroacetate
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| PDQ_Closed_Trial_Search_ID | 582893
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| code | C73591
|
| prefixIRI | NCIT:C73591
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| in_subset |
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| Display_Name | Sodium Dichloroacetate
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| Preferred_Name | Sodium Dichloroacetate
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| FDA_UNII_Code | 42932X67B5
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C2HCl2O2.Na
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| Maps_To | Sodium Dichloroacetate
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| CAS_Registry | 2156-56-1
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| NCI_Drug_Dictionary_ID | 582893
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| Legacy Concept Name | Sodium_Dichloroacetate
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 582893
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0037501
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