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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C73307
http://purl.obolibrary.org/obo/NCIT_C73307
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|---|---|
| Preferred Name | Bisnafide Dimesylate |
| Definitions |
The dimesylate salt form of bisnafide, a bis-naphthalimide compound with anticancer activity. Bisnafide selectively intercalates guanine-cytosine (GC) rich regions of DNA, thereby interfering with DNA replication machinery and activity of topoisomerase II. As a result, this agent causes potent cytotoxicity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The dimesylate salt form of bisnafide, a bis-naphthalimide compound with anticancer activity. Bisnafide selectively intercalates guanine-cytosine (GC) rich regions of DNA, thereby interfering with DNA replication machinery and activity of topoisomerase II. As a result, this agent causes potent cytotoxicity. |
|---|---|
| prefLabel | Bisnafide Dimesylate
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| label | Bisnafide Dimesylate
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| code | C73307
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| prefixIRI | NCIT:C73307
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| in_subset | |
| Preferred_Name | Bisnafide Dimesylate
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| FDA_UNII_Code | J30IBO0LMA
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| Contributing_Source | FDA
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| Chemical_Formula | C32H28N6O8.2CH4O3S
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| Maps_To | Bisnafide Dimesylate
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| CAS_Registry | 145124-30-7
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| Legacy Concept Name | Bisnafide_Dimesylate
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2347031
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