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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C73261
http://purl.obolibrary.org/obo/NCIT_C73261
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|---|---|
| Preferred Name | Bendamustine |
| Definitions |
A bifunctional mechlorethamine derivative with alkylating and antimetabolite activities. Although the exact mechanism of action of bendamustine is unknown, this agent appears to alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and eventually the induction of apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bifunctional mechlorethamine derivative with alkylating and antimetabolite activities. Although the exact mechanism of action of bendamustine is unknown, this agent appears to alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and eventually the induction of apoptosis. |
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| label | Bendamustine
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| prefLabel | Bendamustine
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| Legacy Concept Name | Bendamustine
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| in_subset |
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| Preferred_Name | Bendamustine
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C16H21Cl2N3O2
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| Maps_To | Bendamustine
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| UMLS_CUI | C0525079
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| FDA_UNII_Code | 9266D9P3PQ
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| prefixIRI | NCIT:C73261
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| Accepted_Therapeutic_Use_For | Chronic Lymphocytic Leukemia, Indolent B-cell non-Hodgkin Lymphoma
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| Contributing_Source |
FDA
PCDC
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| subClassOf | |
| Has_Salt_Form | |
| code | C73261
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| type | |
| ALT_DEFINITION | The active ingredient in a drug that is used to treat chronic lymphocytic leukemia (CLL), to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within 6 months of treatment with other anticancer drugs, and is being studied in the treatment of other types of cancer. Bendamustine may damage the DNA in cancer cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite.
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 16506-27-7
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