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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C73241
http://purl.obolibrary.org/obo/NCIT_C73241
|
|---|---|
| Preferred Name | Retelliptine |
| Definitions |
An ellipticine derivative and topoisomerase II inhibitor with antineoplastic activity. Retelliptine intercalates with DNA and inhibits topoisomerase II during DNA replication. In addition, this agent appears to induce cell cycle arrest at G2/M phase and apoptosis mediated through the Fas/Fas ligand death receptor and the mitochondrial pathway.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An ellipticine derivative and topoisomerase II inhibitor with antineoplastic activity. Retelliptine intercalates with DNA and inhibits topoisomerase II during DNA replication. In addition, this agent appears to induce cell cycle arrest at G2/M phase and apoptosis mediated through the Fas/Fas ligand death receptor and the mitochondrial pathway. |
|---|---|
| prefLabel | Retelliptine
|
| label | Retelliptine
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| code | C73241
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| prefixIRI | NCIT:C73241
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| in_subset | |
| Preferred_Name | Retelliptine
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| FDA_UNII_Code | SZ0F94M68J
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| Contributing_Source | FDA
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| Chemical_Formula | C25H32N4O
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| Maps_To | Retelliptine
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| CAS_Registry | 72238-02-9
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| Legacy Concept Name | Retelliptine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0084319
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