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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C73236
http://purl.obolibrary.org/obo/NCIT_C73236
|
|---|---|
| Preferred Name | Etoprine |
| Definitions |
A lipophilic, diaminopyrimidine folate antagonist with potential antineoplastic activity. Etoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism. This may eventually result in a reduction of cellular growth and the induction of apoptosis. In addition, this agent inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble etoprine is capable of crossing the blood-brain barrier.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A lipophilic, diaminopyrimidine folate antagonist with potential antineoplastic activity. Etoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism. This may eventually result in a reduction of cellular growth and the induction of apoptosis. In addition, this agent inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble etoprine is capable of crossing the blood-brain barrier. |
|---|---|
| prefLabel | Etoprine
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| label | Etoprine
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| code | C73236
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| prefixIRI | NCIT:C73236
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| in_subset | |
| Preferred_Name | Etoprine
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| FDA_UNII_Code | 406PGU9KGI
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| Contributing_Source | FDA
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| Chemical_Formula | C12H12Cl2N4
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| Maps_To | Etoprine
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| CAS_Registry | 18588-57-3
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| NSC Number | 3062
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| Legacy Concept Name | Etoprine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0059875
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