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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C732
http://purl.obolibrary.org/obo/NCIT_C732
|
|---|---|
| Preferred Name | Pentostatin |
| Definitions |
A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04) |
|---|---|
| prefLabel | Pentostatin
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| label | Pentostatin
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| PDQ_Closed_Trial_Search_ID | 39210
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| code | C732
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| Has_Target | |
| prefixIRI | NCIT:C732
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| in_subset |
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| Display_Name | Pentostatin
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| Preferred_Name | Pentostatin
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| FDA_UNII_Code | 395575MZO7
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C11H16N4O4
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| Maps_To | Pentostatin
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| CAS_Registry |
53910-25-1
63677-95-2
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| NSC Number |
218321
247520
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| NCI_Drug_Dictionary_ID | 39210
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| Legacy Concept Name | Pentostatin
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| type | |
| ALT_DEFINITION | The active ingredient in a drug that is used to treat hairy cell leukemia and is being studied in the treatment of other types of cancer. Pentostatin blocks a protein needed for cell growth and may kill cancer cells. It is made by a bacterium. It is a type of adenosine deaminase inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39210
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| Accepted_Therapeutic_Use_For | Chronic lymphocytic leukemia; Cutaneous t-cell lymphoma; Hairy cell leukemia
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
Antibiotic
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| UMLS_CUI | C0030896
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