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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C729
http://purl.obolibrary.org/obo/NCIT_C729
|
|---|---|
| Preferred Name | Penicillamine |
| Definitions |
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04) |
|---|---|
| prefLabel | Penicillamine
|
| label | Penicillamine
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| CHEBI_ID | CHEBI:7959
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| PDQ_Closed_Trial_Search_ID | 42546
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| code | C729
|
| prefixIRI | NCIT:C729
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| in_subset | |
| Preferred_Name | Penicillamine
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| FDA_UNII_Code | GNN1DV99GX
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| Contributing_Source | FDA
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| Chemical_Formula | C5H11NO2S
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| Maps_To | Penicillamine
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| CAS_Registry | 52-67-5
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| NSC Number | 81549
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| NCI_Drug_Dictionary_ID | 42546
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| Legacy Concept Name | Penicillamine
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| type | |
| ALT_DEFINITION | A drug that removes copper from the body and is used to treat diseases in which there is an excess of this metal. It is also being studied as a possible angiogenesis inhibitor in brain tumors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42546
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| Accepted_Therapeutic_Use_For | Wilsons disease; heavy metal intoxication; cystinuria; rheumatoid arthritis; primary biliary cirrhosis; Feltys syndrome; rheumatoid vasculitis
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0030817
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| Delete | Subject | Author | Type | Created |
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