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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C72829
http://purl.obolibrary.org/obo/NCIT_C72829
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|---|---|
| Preferred Name | Piroxantrone Hydrochloride |
| Definitions |
The hydrochloride salt form of piroxantrone, an anthrapyrazole antineoplastic antibiotic. Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt form of piroxantrone, an anthrapyrazole antineoplastic antibiotic. Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity. |
|---|---|
| prefLabel | Piroxantrone Hydrochloride
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| label | Piroxantrone Hydrochloride
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| code | C72829
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| prefixIRI | NCIT:C72829
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| in_subset | |
| Preferred_Name | Piroxantrone Hydrochloride
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| FDA_UNII_Code | PS51OZG63Z
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| Contributing_Source | FDA
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| Chemical_Formula | C21H25N5O4.2HCl
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| Maps_To | Piroxantrone Hydrochloride
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| CAS_Registry | 105118-12-5
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| Legacy Concept Name | Piroxantrone_Hydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2347520
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