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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C72077
http://purl.obolibrary.org/obo/NCIT_C72077
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|---|---|
| Preferred Name | Losoxantrone Hydrochloride |
| Definitions |
The hydrochloride salt form of losoxantrone, an anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Losoxantrone is less cardiotoxic than doxorubicin.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt form of losoxantrone, an anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Losoxantrone is less cardiotoxic than doxorubicin. |
|---|---|
| prefLabel | Losoxantrone Hydrochloride
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| label | Losoxantrone Hydrochloride
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| code | C72077
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| prefixIRI | NCIT:C72077
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| in_subset | |
| Preferred_Name | Losoxantrone Hydrochloride
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| FDA_UNII_Code | W6E275IURX
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| Contributing_Source | FDA
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| Chemical_Formula | 2C22H27N5O4.4ClH.H2O
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| Maps_To | Losoxantrone Hydrochloride
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| CAS_Registry | 132937-89-4
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| NSC Number | 357885
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| Legacy Concept Name | Losoxantrone_Hydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2346902
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