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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C71743
http://purl.obolibrary.org/obo/NCIT_C71743
|
|---|---|
| Preferred Name | IL-2 Recombinant Fusion Protein ALT-801 |
| Definitions |
A recombinant protein consisting of the cytokine interleukin-2 (IL-2) fused to a humanized soluble T-cell receptor (TCR) directed against a tumor suppressor p53-derived antigen with potential immunopotentiating and antineoplastic activities. The TCR moiety of IL-2 recombinant fusion protein ALT-801 binds to tumor cells displaying p53 epitope/MHC complexes; subsequently, the tumor cell-localized IL-2 moiety may stimulate natural killer (NK) cell and T cell cytotoxic immune responses against p53-expressing tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant protein consisting of the cytokine interleukin-2 (IL-2) fused to a humanized soluble T-cell receptor (TCR) directed against a tumor suppressor p53-derived antigen with potential immunopotentiating and antineoplastic activities. The TCR moiety of IL-2 recombinant fusion protein ALT-801 binds to tumor cells displaying p53 epitope/MHC complexes; subsequently, the tumor cell-localized IL-2 moiety may stimulate natural killer (NK) cell and T cell cytotoxic immune responses against p53-expressing tumor cells. |
|---|---|
| prefLabel | IL-2 Recombinant Fusion Protein ALT-801
|
| label | IL-2 Recombinant Fusion Protein ALT-801
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| PDQ_Closed_Trial_Search_ID | 560749
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| code | C71743
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| Has_Target | |
| prefixIRI | NCIT:C71743
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| in_subset |
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| Display_Name | IL-2 Recombinant Fusion Protein ALT-801
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| Preferred_Name | IL-2 Recombinant Fusion Protein ALT-801
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| FDA_UNII_Code | QWZ40O5W6K
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| Contributing_Source |
CTRP
FDA
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| Maps_To | IL-2 Recombinant Fusion Protein ALT-801
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| CAS_Registry | 1188450-53-4
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| NCI_Drug_Dictionary_ID | 560749
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| Legacy Concept Name | IL-2_Recombinant_Fusion_Protein_ALT-801
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 560749
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C2346454
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