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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C71734
http://purl.obolibrary.org/obo/NCIT_C71734
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|---|---|
| Preferred Name | Nifurtimox |
| Definitions |
A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function. |
|---|---|
| prefLabel | Nifurtimox
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| label | Nifurtimox
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| PDQ_Closed_Trial_Search_ID | 558911
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| code | C71734
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| prefixIRI | NCIT:C71734
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| in_subset | |
| Preferred_Name | Nifurtimox
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| FDA_UNII_Code | M84I3K7C2O
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| Contributing_Source | FDA
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| Chemical_Formula | C10H13N3O5S
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| Maps_To | Nifurtimox
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| CAS_Registry | 23256-30-6
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| NCI_Drug_Dictionary_ID | 558911
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| Legacy Concept Name | Nifurtimox
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 558911
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0028073
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