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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C71711
http://purl.obolibrary.org/obo/NCIT_C71711
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|---|---|
| Preferred Name | Pan-AKT Kinase Inhibitor GSK690693 |
| Definitions |
An aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport. |
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| prefLabel | Pan-AKT Kinase Inhibitor GSK690693
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| label | Pan-AKT Kinase Inhibitor GSK690693
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| PDQ_Closed_Trial_Search_ID | 560189
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| code | C71711
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| Has_Target | |
| prefixIRI | NCIT:C71711
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| in_subset |
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| Display_Name | Pan-AKT Kinase Inhibitor GSK690693
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| Preferred_Name | Pan-AKT Kinase Inhibitor GSK690693
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| FDA_UNII_Code | GWH480321B
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Pan-AKT Kinase Inhibitor GSK690693
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| CAS_Registry | 937174-76-0
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| NCI_Drug_Dictionary_ID | 560189
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| Legacy Concept Name | Pan-AKT_Inhibitor_GSK-690693
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 560189
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2347443
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