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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C71710
http://purl.obolibrary.org/obo/NCIT_C71710
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|---|---|
| Preferred Name | Receptor Tyrosine Kinase Inhibitor R1530 |
| Definitions |
A pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. Mitosis-angiogenesis inhibitor (MAI) R1530 inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta, FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. Mitosis-angiogenesis inhibitor (MAI) R1530 inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta, FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis. |
|---|---|
| prefLabel | Receptor Tyrosine Kinase Inhibitor R1530
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| label | Receptor Tyrosine Kinase Inhibitor R1530
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| NCI_META_CUI | CL376137
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| PDQ_Closed_Trial_Search_ID | 560180
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| code | C71710
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| Has_Target |
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| prefixIRI | NCIT:C71710
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| in_subset |
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| Display_Name | Receptor Tyrosine Kinase Inhibitor R1530
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| Preferred_Name | Receptor Tyrosine Kinase Inhibitor R1530
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| Contributing_Source | CTRP
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| Maps_To | Receptor Tyrosine Kinase Inhibitor R1530
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| NCI_Drug_Dictionary_ID | 560180
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| Legacy Concept Name | Mitosis_and_Apoptosis_Inhibitor_R1530
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 560180
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| Semantic_Type | Pharmacologic Substance
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