Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C71693
http://purl.obolibrary.org/obo/NCIT_C71693
Preferred Name

Apomab
Definitions
A fully human monoclonal antibody directed against human death receptor 5 (DR5; TRAIL-R2; TNFRSF10B) with potential pro-apoptotic and antineoplastic activities. Mimicking the natural ligand TRAIL (tumor necrosis factor-related apoptosis inducing ligand), apomab binds to DR5, which may directly activate the extrinsic apoptosis pathway and indirectly induce the intrinsic apoptosis pathway in tumor cells. DR5 is a cell surface receptor of the TNF-receptor superfamily and is expressed in a broad range of cancers.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A fully human monoclonal antibody directed against human death receptor 5 (DR5; TRAIL-R2; TNFRSF10B) with potential pro-apoptotic and antineoplastic activities. Mimicking the natural ligand TRAIL (tumor necrosis factor-related apoptosis inducing ligand), apomab binds to DR5, which may directly activate the extrinsic apoptosis pathway and indirectly induce the intrinsic apoptosis pathway in tumor cells. DR5 is a cell surface receptor of the TNF-receptor superfamily and is expressed in a broad range of cancers.
prefLabel
Apomab
label
Apomab
PDQ_Closed_Trial_Search_ID
555507
code
C71693
Has_Target
prefixIRI
NCIT:C71693
in_subset
Display_Name
Apomab
Preferred_Name
Apomab
FDA_UNII_Code
703KLX5LXZ
Contributing_Source
CTRP
FDA
Maps_To
Apomab
CAS_Registry
1108170-71-3
NCI_Drug_Dictionary_ID
555507
Legacy Concept Name
Apomab
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
555507
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
UMLS_CUI
C2346838
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