Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C71633
http://purl.obolibrary.org/obo/NCIT_C71633
Preferred Name

Pioglitazone
Definitions
An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.
prefLabel
Pioglitazone
label
Pioglitazone
Has_Salt_Form
CHEBI_ID
CHEBI:8228
code
C71633
prefixIRI
NCIT:C71633
in_subset
Display_Name
Pioglitazone
Preferred_Name
Pioglitazone
FDA_UNII_Code
X4OV71U42S
Contributing_Source
CTRP
FDA
Chemical_Formula
C19H20N2O3S
Maps_To
Pioglitazone
CAS_Registry
111025-46-8
Legacy Concept Name
Pioglitazone_Base
type
ALT_DEFINITION
A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione.
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0071097
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display