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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C71622
http://purl.obolibrary.org/obo/NCIT_C71622
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|---|---|
| Preferred Name | Sunitinib |
| Definitions |
An indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells. |
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| prefLabel | Sunitinib
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| label | Sunitinib
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:38940
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| code | C71622
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| Has_Target |
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| prefixIRI | NCIT:C71622
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| in_subset |
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| Display_Name | Sunitinib
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| Preferred_Name | Sunitinib
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| FDA_UNII_Code | V99T50803M
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C22H27FN4O2
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| Maps_To | Sunitinib
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| CAS_Registry | 557795-19-4
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| Legacy Concept Name | Sunitinib
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| type | |
| ALT_DEFINITION | A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). Sunitinib is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1176020
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