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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C71603
http://purl.obolibrary.org/obo/NCIT_C71603
|
|---|---|
| Preferred Name | Cytarabine Hydrochloride |
| Definitions |
The hydrochloride form of cytarabine, an antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride form of cytarabine, an antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. |
|---|---|
| label | Cytarabine Hydrochloride
|
| prefLabel | Cytarabine Hydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| Legacy Concept Name | Cytarabine_Hydrochloride
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| in_subset | |
| Preferred_Name | Cytarabine Hydrochloride
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| Chemical_Formula | C9H13N3O5.HCl
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| Display_Name | Cytarabine Hydrochloride
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| UMLS_CUI | C0282120
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| FDA_UNII_Code | 33K3DB6591
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| prefixIRI | NCIT:C71603
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C71603
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| type | |
| NSC Number | 63878
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| CAS_Registry | 69-74-9
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| Delete | Subject | Author | Type | Created |
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| No notes to display |