Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C71535
http://purl.obolibrary.org/obo/NCIT_C71535
Preferred Name

Indoximod
Definitions
A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
prefLabel
Indoximod
label
Indoximod
PDQ_Closed_Trial_Search_ID
579646
code
C71535
Has_Target
prefixIRI
NCIT:C71535
in_subset
Display_Name
Indoximod
Preferred_Name
Indoximod
FDA_UNII_Code
TX5CYN1KMZ
Contributing_Source
CTRP
FDA
Maps_To
Indoximod
CAS_Registry
110117-83-4
NCI_Drug_Dictionary_ID
579646
Legacy Concept Name
_1-Methyl-d-Tryptophan
type
ALT_DEFINITION
A substance being studied in the treatment of melanoma and many other types of cancer. 1-methyl-d-tryptophan blocks the breakdown of the amino acid tryptophan, which is needed for T cells (a type of immune system cell) to kill tumor cells. Giving 1-methyl-d-tryptophan to patients who have received chemotherapy for cancer may help kill more tumor cells. It is a type of enzyme inhibitor and immunosuppressant.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
579646
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C4045546
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display