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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C71529
http://purl.obolibrary.org/obo/NCIT_C71529
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|---|---|
| Preferred Name | Serine/Threonine Kinase Inhibitor CBP501 |
| Definitions |
A peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle. |
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| prefLabel | Serine/Threonine Kinase Inhibitor CBP501
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| label | Serine/Threonine Kinase Inhibitor CBP501
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| PDQ_Closed_Trial_Search_ID | 577812
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| code | C71529
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| Has_Target | |
| prefixIRI | NCIT:C71529
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| in_subset |
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| Display_Name | Serine/Threonine Kinase Inhibitor CBP501
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| Preferred_Name | Serine/Threonine Kinase Inhibitor CBP501
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| FDA_UNII_Code | XH2662798I
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Serine/Threonine Kinase Inhibitor CBP501
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| CAS_Registry | 565434-85-7
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| NCI_Drug_Dictionary_ID | 577812
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| Legacy Concept Name | Serine_Threonine_Kinase_Inhibitor_CBP501
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 577812
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2348193
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