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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C71157
http://purl.obolibrary.org/obo/NCIT_C71157
|
|---|---|
| Preferred Name | Anti-PSCA Monoclonal Antibody AGS-1C4D4 |
| Definitions |
An IgG1k fully human monoclonal antibody directed against the human prostate stem cell antigen (PSCA) with potential antineoplastic activity. Anti-PSCA fully human monoclonal antibody MK4721 selectively targets and binds to PSCA, triggering complement-dependent cell lysis and antibody-dependent cell-mediated cytotoxicity in tumor cells expressing PSCA. PSCA is a glycosyl-phosphatidylinositol (GPI)-linked cell surface antigen found in cancers of the bladder, pancreas, and prostate.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An IgG1k fully human monoclonal antibody directed against the human prostate stem cell antigen (PSCA) with potential antineoplastic activity. Anti-PSCA fully human monoclonal antibody MK4721 selectively targets and binds to PSCA, triggering complement-dependent cell lysis and antibody-dependent cell-mediated cytotoxicity in tumor cells expressing PSCA. PSCA is a glycosyl-phosphatidylinositol (GPI)-linked cell surface antigen found in cancers of the bladder, pancreas, and prostate. |
|---|---|
| prefLabel | Anti-PSCA Monoclonal Antibody AGS-1C4D4
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| label | Anti-PSCA Monoclonal Antibody AGS-1C4D4
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| PDQ_Closed_Trial_Search_ID | 570981
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| code | C71157
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| Has_Target | |
| prefixIRI | NCIT:C71157
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| in_subset |
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| Display_Name | Anti-PSCA Monoclonal Antibody AGS-1C4D4
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| Preferred_Name | Anti-PSCA Monoclonal Antibody AGS-1C4D4
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| FDA_UNII_Code | L0505LPC7O
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-PSCA Monoclonal Antibody AGS-1C4D4
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| NCI_Drug_Dictionary_ID | 570981
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| Legacy Concept Name | Monoclonal_Antibody_MK4721
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 570981
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| UMLS_CUI | C2347292
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