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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C711
http://purl.obolibrary.org/obo/NCIT_C711
|
|---|---|
| Preferred Name | Octreotide |
| Definitions |
A synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone. |
|---|---|
| prefLabel | Octreotide
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| label | Octreotide
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:7726
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| code | C711
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| prefixIRI | NCIT:C711
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| in_subset |
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| Display_Name | Octreotide
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| Preferred_Name | Octreotide
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| FDA_UNII_Code | RWM8CCW8GP
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C49H66N10O10S2
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| Maps_To | Octreotide
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| CAS_Registry | 83150-76-9
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| Legacy Concept Name | Octreotide
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| PubMedID_Primary_Reference | 16917205
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| type | |
| ALT_DEFINITION | A drug similar to the naturally occurring growth hormone inhibitor somatostatin. Octreotide is used to treat diarrhea and flushing associated with certain types of tumors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| Accepted_Therapeutic_Use_For | Acromegaly; Diarrhea
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0028833
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