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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C70982
http://purl.obolibrary.org/obo/NCIT_C70982
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|---|---|
| Preferred Name | Linsitinib |
| Definitions |
An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis. |
|---|---|
| label | Linsitinib
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| prefLabel | Linsitinib
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| Legacy Concept Name | IGF-1R_Inhibitor_OSI-906
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| in_subset |
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| Preferred_Name | Linsitinib
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C26H23N5O
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| Display_Name | Linsitinib
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| Maps_To | Linsitinib
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| PDQ_Open_Trial_Search_ID | 566191
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| Has_Target | |
| UMLS_CUI | C2346449
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| FDA_UNII_Code | 15A52GPT8T
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| prefixIRI | NCIT:C70982
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| NCI_Drug_Dictionary_ID | 566191
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C70982
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It blocks a protein called IGF-1R, which is found at high levels in some types of tumors. IGF-1R is needed for cell growth and blocking it may cause tumor cells to die. IGF-1R inhibitor OSI-906 is a type of IGF-1R inhibitor.
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| PDQ_Closed_Trial_Search_ID | 566191
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 867160-71-2
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