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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C70981
http://purl.obolibrary.org/obo/NCIT_C70981
|
|---|---|
| Preferred Name | Tyrosine Kinase Inhibitor OSI-930 |
| Definitions |
A selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI-930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c-Kit and VEGFR2 are overexpressed in a variety of cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI-930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c-Kit and VEGFR2 are overexpressed in a variety of cancers. |
|---|---|
| prefLabel | Tyrosine Kinase Inhibitor OSI-930
|
| label | Tyrosine Kinase Inhibitor OSI-930
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| PDQ_Closed_Trial_Search_ID | 566188
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| code | C70981
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| prefixIRI | NCIT:C70981
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| in_subset | |
| Preferred_Name | Tyrosine Kinase Inhibitor OSI-930
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| FDA_UNII_Code | G1PEG5Q9Y2
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| Contributing_Source | FDA
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| Maps_To | Tyrosine Kinase Inhibitor OSI-930
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| CAS_Registry | 728033-96-3
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| NCI_Drug_Dictionary_ID | 566188
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| Legacy Concept Name | Tyrosine_Kinase_Inhibitor_OSI-930
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 566188
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1615605
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