Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C70948
http://purl.obolibrary.org/obo/NCIT_C70948
Preferred Name

Polo-like Kinase 1 Inhibitor GSK461364
Definitions
A small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.
label
Polo-like Kinase 1 Inhibitor GSK461364
prefLabel
Polo-like Kinase 1 Inhibitor GSK461364
Legacy Concept Name
Polo-like_Kinase_1_Inhibitor_GSK461364
in_subset
Preferred_Name
Polo-like Kinase 1 Inhibitor GSK461364
Is_Value_For_GDC_Property
Maps_To
Polo-like Kinase 1 Inhibitor GSK461364
PDQ_Open_Trial_Search_ID
573587
Has_Target
UMLS_CUI
C2347618
prefixIRI
NCIT:C70948
NCI_Drug_Dictionary_ID
573587
subClassOf
code
C70948
type
PDQ_Closed_Trial_Search_ID
573587
Semantic_Type
Pharmacologic Substance
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