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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C69135
http://purl.obolibrary.org/obo/NCIT_C69135
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|---|---|
| Preferred Name | RAF Kinase Inhibitor XL281 |
| Definitions |
An orally active, small molecule with potential antineoplastic activity. XL281 specifically inhibits RAF kinases, located downstream from RAS in the RAS/RAF/MEK/ERK kinase signaling pathway, which may result in reduced proliferation of tumor cells. RAS mutations may result in constitutive activation of the RAS/RAF/MEK/ERK kinase signaling pathway, and have been found to occur frequently in human tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally active, small molecule with potential antineoplastic activity. XL281 specifically inhibits RAF kinases, located downstream from RAS in the RAS/RAF/MEK/ERK kinase signaling pathway, which may result in reduced proliferation of tumor cells. RAS mutations may result in constitutive activation of the RAS/RAF/MEK/ERK kinase signaling pathway, and have been found to occur frequently in human tumors. |
|---|---|
| prefLabel | RAF Kinase Inhibitor XL281
|
| label | RAF Kinase Inhibitor XL281
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| NCI_META_CUI | CL371855
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| PDQ_Closed_Trial_Search_ID | 543515
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| code | C69135
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| Has_Target | |
| prefixIRI | NCIT:C69135
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| in_subset |
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| Display_Name | RAF Kinase Inhibitor XL281
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| Preferred_Name | RAF Kinase Inhibitor XL281
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| Contributing_Source | CTRP
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| Maps_To | RAF Kinase Inhibitor XL281
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| NCI_Drug_Dictionary_ID | 543515
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| Legacy Concept Name | RAF_Kinase_Inhibitor_XL281
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 543515
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| Semantic_Type | Pharmacologic Substance
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