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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C68963
http://purl.obolibrary.org/obo/NCIT_C68963
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|---|---|
| Preferred Name | Serine/Threonine Kinase Inhibitor XL418 |
| Definitions |
A selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells. |
|---|---|
| prefLabel | Serine/Threonine Kinase Inhibitor XL418
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| label | Serine/Threonine Kinase Inhibitor XL418
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| NCI_META_CUI | CL374493
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| PDQ_Closed_Trial_Search_ID | 546978
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| code | C68963
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| Has_Target | |
| prefixIRI | NCIT:C68963
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| in_subset | |
| Preferred_Name | Serine/Threonine Kinase Inhibitor XL418
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| FDA_UNII_Code | OLJ18SRI8A
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| Contributing_Source | FDA
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| Maps_To | Serine/Threonine Kinase Inhibitor XL418
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| CAS_Registry | 871343-09-8
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| NCI_Drug_Dictionary_ID | 546978
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| Legacy Concept Name | Serine_Threonine_Kinase_Inhibitor_XL418
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 546978
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| Semantic_Type | Pharmacologic Substance
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