Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Therapeutic Hemin
Synonyms
Definitions

A sterile, lyophilized powder of hemin, the Fe3+ oxidation product of heme (Fe2+), derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway, resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors. The mechanism by which therapeutic hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been determined.
ID

http://purl.obolibrary.org/obo/NCIT_C68925
code

C68925
definition

A sterile, lyophilized powder of hemin, the Fe3+ oxidation product of heme (Fe2+), derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway, resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors. The mechanism by which therapeutic hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been determined.
in_subset

http://purl.obolibrary.org/obo/NCIT_C176424
label

Therapeutic Hemin
Legacy Concept Name

Therapeutic_Hemin
NCI_Drug_Dictionary_ID

549706
PDQ_Closed_Trial_Search_ID

549706
PDQ_Open_Trial_Search_ID

549706
Preferred_Name

Therapeutic Hemin
prefixIRI

NCIT:C68925
prefLabel

Therapeutic Hemin
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0030316
subClassOf

http://purl.obolibrary.org/obo/NCIT_C471
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